Abstract: Vacuum pumps and vacuum butterfly valves are widely used in the vacuum control process of environmental simulation devices. However, limited research has been conducted on the adaptability of variable-frequency vacuum pumps during pressure stabilization and the throttling characteristics of butterfly valves coupled with pipelines. To address this, this study designed a stabilization control system utilizing both components. Computational Fluid Dynamics (CFD) was employed to calculate the mass flow rate required for maintaining pressure stability across different flow regimes and to assess the impact of this stabilized flow on vacuum pump operation. Furthermore, the flow rate characteristics and control accuracy of two typical small-diameter butterfly valves integrated with pipelines were investigated. Results demonstrated that pressure stabilization at 1×10⁴ Pa and 5×10³ Pa was achieved within 250 seconds with 0.5% control accuracy, and 1×10³ Pa with 0.2% accuracy. Upstream mass flow controllers are essential for small-diameter valves to meet variable-frequency vacuum pump demand variations. Comparative analysis clarified the flow characteristic and control accuracy advantages of the two valve types after pipeline coupling, establishing correlations between effective opening ranges, throttling behaviors, and control precision across pressure stabilization segments, and the selection of variable-frequency vacuum pumps and butterfly valve configurations in environmental simulation equipment provides theoretical support and technical reference.