Abstract: The high-temperature compression test was conducted on the solution-treated Ti₆₁Al₁₆Cr₁₀Nb₈V₅ multi-principal element alloy (referred to as the Ti61V5 alloy) to obtain its processing map, which was further used to determine the optimal hot rolling process parameters: temperature range of 920–1030℃, strain rate of 0.001 /s–0.01 /s, and a single-pass engineering strain of 22%–36%. The Ti61V5 alloy was hot rolled using the controlled variable method, revealing that as the rolling temperature increased and the strain level rose, the strength initially increased and then decreased, while the ductility gradually improved. The variation in strength was attributed to the initial increase and subsequent decrease in grain refinement strengthening, whereas the increase in ductility was associated with the gradual reduction of dislocation strengthening. When hot rolling was performed at 980℃ with a strain rate of 0.001 /s, a single-pass strain of 30%, and a total strain of 90%, the Ti61V5 alloy sheet exhibited a tensile strength of 1200 MPa and an elongation of 18%. Compared with the solution-treated state, the strength increased by approximately 63.7%, and the ductility improved by about 45%.