Abstract: The demand for quadrupole mass spectrometers in various industries is continuously increasing. China has gradually started research on high-precision quadrupole mass spectrometers, thus putting forward higher requirements for the performance of radio frequency (RF) power supplies. Based on the theory of quadrupole electric fields and the influencing factors of electrical parameters, the ion optical simulation software SIMION was used to model and simulate the electric field motion and ion trajectories for different electrical parameters. The simulation results show that under the given simulation parameters, increasing the bias voltage can reduce the ion incident energy, thereby improving the resolution to a certain extent. However, due to the greater influence of the fringe field on large-mass ions, the pass rate of large-mass ions decreases significantly. Increasing the power supply frequency can improve the resolution of the quadrupole mass spectrometer, but it will deteriorate the instrument sensitivity. At the same time, the high frequency will lead to an increase in the corresponding voltage, increasing the manufacturing difficulty of the power supply. Increasing the DC/RF ratio will reduce the ion pass rate and improve the resolution. However, due to the non-linearity of the stability region under the same DC/RF ratio, the resolution of large-mass numbers is significantly worse than that of small-mass numbers. In actual production, different DC/RF ratios may need to be considered to meet the requirements. The above results provide theoretical support for the development and application of RF power supplies.