Abstract: In this study, a micrometer-thick monolayer porous resistive strain sensing film was prepared based on droplet microfluidic technology, and the effects of different resins, curing agent mass ratios on the deformation degree of the flexible sensing film were investigated. The results show that the micrometer-thick porous film prepared with a mass ratio of resin to curing agent of 30:1 has good tensile properties, and the pores within the porous film form a monolayer distribution, with a relatively uniform pore size and a relatively homogeneous distribution. The porous resistive strain sensor prepared based on this film has a wide response range (50% strain), high sensitivity (GF=602.92, 40%<ε<50%), low detection limit (0.1% strain), satisfactory stability and durability (1,000 dynamic responses), and the use of the sensor that is able to monitor the human body's micro-physiological signals and joint movement, but also can monitor the gripping signals of manipulators grasping objects of different sizes, therefore, there is a certain potential for the application of this sensor in the fields of wearable electronic devices and soft robots.