Abstract: The vacuum safety interlock system of the beamline station is an important basis for guaranteeing the safe operation of the storage ring and the safety of equipment on the beamline station. The latest design method of the vacuum safety interlock system for the beamline and its stations, which is being newly built at Hefei Light Source is introduced. Based on the latest programmable logic controller (PLC) and virtualization technologies under the architecture of the open software platform EPICS 7 (Experimental Physics and Industrial Control System), a new vacuum safety interlock system for the beamline and its stations has been developed. In the development of the operator interface (OPI) for remote control of the system, a Python script is used to automatically generate OPI with one click, which improves the efficiency of system development. Overall, this design improves the system performance and user experience of human-computer interaction while ensuring the safety and reliability of the system. These design methods provide technical reserves and practical experience for the control of the beamline at the Hefei Advanced Light Facility under construction.